PPM1B Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.

Research Area: Cancer, Cell Biology, Signal transduction

Synonyms:
MGC21657, OTTHUMP00000158953, OTTHUMP00000158954, OTTHUMP00000158955, OTTHUMP00000202394, OTTHUMP00000202395, OTTHUMP00000202399, PP2C beta, PP2C beta X, PP2C-beta, PP2CB, PP2Cbeta, PPC2BETAX, PPM 1B, Ppm1b, PPM1B, Protein phosphatase 1B (formerly 2C) magnesium dependent beta isoform, Protein phosphatase 1B, Protein phosphatase 1B magnesium dependent beta isoform, Protein phosphatase 2C beta isoform, Protein phosphatase 2C isoform beta, Protein phosphatase 2C like protein, Protein phosphatase, Mg2+/Mn2+ dependent, 1B

Immunogen: Fusion protein of human PPM1B

Swissprot: O75688
Gene Accession: BC012002

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.44 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.