PPM1D polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP13875C
Catalog Number: AC-AP13875C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33957
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33957
Applications: WB
Datasheet
Request Information
Background:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Other Names:
Protein phosphatase 1D, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1
Target/Specificity:
This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D.
Antigen Region:
183-212
Antigen Type: Synthetic Peptide
Gene Name: PPM1D
Gene ID: 8493
Primary Accession: O15297
NCBI Accession: NP_003611.1
Other Accession: Q9QZ67; NP_003611.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Other Names:
Protein phosphatase 1D, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1
Target/Specificity:
This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D.
Antigen Region:
183-212
Antigen Type: Synthetic Peptide
Gene Name: PPM1D
Gene ID: 8493
Primary Accession: O15297
NCBI Accession: NP_003611.1
Other Accession: Q9QZ67; NP_003611.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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