PPP1R12A Polyclonal Antibody

Background:
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
M130, MBS, Myosin binding subunit, Myosin phosphatase target subunit 1, Myosin phosphatase targeting subunit 1, Myosin phosphatase-targeting subunit 1, MYPT1, MYPT1, PPP1R12A, Protein phosphatase 1 regulatory inhibitor subunit 12A, Protein phosphatase 1 regulatory subunit 12A, Protein phosphatase 1, regulatory (inhibitor) subunit 12A, Protein phosphatase myosin binding subunit, Protein phosphatase myosin-binding subunit

Immunogen: Recombinant protein of human PPP1R12A

Swissprot: O14974
Gene Accession: BC111752

Calculated MW: 115 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:200-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-17434/sc-17433/sc-34142/sc-34143/sc-25618

Citation(s):
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.8b01023