PPP1R1A polyclonal, anti-human, mouse, rat

Background:
The inhibitor of protein phosphatase 1 (IPP-1, I-1) plays a role in regulating the phosphorylation of other proteins, and is itself phosphorylated by a cyclic AMP-dependent protein kinase. IPP-1 is present in skeletal muscles and in distinct neuronal systems of the brain. The localization and expression of IPP-1 suggests that it may play discrete roles in certain regions and developing stages of the brain, independent of the regulation of protein phosphatase type 1 (PP-1). PP-1 binds to both phosphorylated and dephosphorylated IPP-1. Conversion of PP-1 to an Mn2+-dependent state appears to play a role in its regulation by IPP-1. IPP-1 attenuates the activity of glycogen phosphorylase and is thought to play an important role in the hormonal control of glycogen metabolism.

Alternative Name:
I-1, IPP-1, PPP1R1A, I 1, I-1, I1, Inhibitor 1, IPP 1, IPP-1, IPP1, Ppp1r1a, PPR1A, Protein phosphatase 1 regulatory (inhibitor) subunit 1A, Protein phosphatase 1 regulatory subunit 1A, Protein phosphatase inhibitor 1,

Application Dilution:
WB:1:1,000
ICC:1:50-1:200
IHC:1:100-1:500
FC:1:50-1:100

Specificity: PPP1R1A polyclonal antibody detects endogenous levels of PPP1R1A protein.

Immunogen:
recombinant protein

MW: 27 kDa

Swiss-Prot: Q13522(Human) Q9ERT9(Mouse) P19103(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.