PPP1R8 Polyclonal Antibody

Background:
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

Research Area: Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
PPP1R8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047

Immunogen: Recombinant fusion protein of human PPP1R8 (NP_612568.1).

Swissprot: Q12972
Gene ID: 5511

Calculated MW: 13 kDa/22 kDa/38 kDa
Observed MW: 40 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.