PRAME Polyclonal Antibody

Background:
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Tags & Cell Markers

Synonyms:
4930534P07Rik, Cancer/testis antigen 130, CT130, MAPE, Melanoma antigen preferentially expressed in tumors, OIP 4, OIP-4, OIP4 , OPA interacting protein 4, Opa interacting protein OIP4, OPA-interacting protein 4, PRAME, PRAME, Preferentially expressed antigen in melanoma , Preferentially expressed antigen of melanoma, RP23-250F8.3

Immunogen: Fusion protein of human PRAME

Swissprot: P78395
Gene Accession: BC014074

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.1 mg/mL
Dilution: IHC 1:40-1:250, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.