PRAME Polyclonal Antibody

Background:
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Tags & Cell Markers

Synonyms:
PRAME, CT130, MAPE, OIP-4, OIP4

Immunogen: Recombinant fusion protein of human PRAME (NP_996839.1).

Swissprot: P78395
Gene ID: 23532

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:20-1:50

Storage:
Store at -20°C. Avoid freeze / thaw cycles.