PRC rabbit polyclonal, anti-human, mouse

Backgroud: The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],function:Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.,induction:Up-regulated by serum (at protein level).,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Colocalizes with NRF1.,subunit:Interacts with CREB1 and NRF1.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.,

Synonyms: PPRC1, KIAA0595, Peroxisome proliferator-activated receptor gamma coactivator-related protein 1, PGC-1-related coactivator, PRC

Gene Name: PPRC1

Gene ID: 23082

SwissProt ID: Q5VV67

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.