PRDM16 polyclonal (N-term), anti-human
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In stock
SKU
AC-AP1216a
Catalog Number: AC-AP1216a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB0589
Applications: IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB0589
Applications: IHC-P
Datasheet
Request Information
Background:
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Other Names:
PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1, MDS1/EVI1-like gene 1, PRDM16, KIAA1675, MEL1, PFM13
Target/Specificity:
This PRDM16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~316 amino acids from the N-terminal region of human PRDM16.
Antigen Region:
1-316
Antigen Type: Recombinant Protein
Gene Name: PRDM16 (HGNC:14000)
Gene ID: 63976
Primary Accession: Q9HAZ2
NCBI Accession: NP_071397.3;NP_955533.2
Other Accession: NP_071397
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Other Names:
PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1, MDS1/EVI1-like gene 1, PRDM16, KIAA1675, MEL1, PFM13
Target/Specificity:
This PRDM16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~316 amino acids from the N-terminal region of human PRDM16.
Antigen Region:
1-316
Antigen Type: Recombinant Protein
Gene Name: PRDM16 (HGNC:14000)
Gene ID: 63976
Primary Accession: Q9HAZ2
NCBI Accession: NP_071397.3;NP_955533.2
Other Accession: NP_071397
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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