Prepro-Neuropeptide Y (C-PON) polyclonal, anti-human, rat

Quantity: 100 µl

Background:
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.

Synonyms:
NPY, PYY4

Isotype: Rabbit Polyclonal

Immunogen:
Synthetic Prepro-NPY 68-97 (C-PON)

Form: Serum containing 0.1% sodium azide

Specificity:
Antisera raised against NPY often cross-react with PP and PYY. This antiserum was raised using a synthetic peptide from the prepro-nPY sequence, which has no homologies to PP and NPY. Absorption with 10-100 ?g immunogen per ml diluted antiserum abolishes the staining.

Reactivity: human, rat

Applications: Immunohistochemistry, suitable for frozen sections

Working DIlution: 1:20 to 1:40 for immunofluorescence microscopy

Positive Control:
Stefanini-fixed sections of rat small intestine

Storage: 2-8C for immediate use, or at -20C (aliquot)