DNA Ligase IV polyclonal, anti-human
€470.00
In stock
SKU
AC-AP69550
Background:
Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends.
Other Names:
LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4
Antigen Type: synthetic peptide
Antigen Type: LIG4 {ECO:0000303|PubMed:16357942, ECO:0000312|HGNC:HGNC:6601}
Gene ID: 3981
Primary Accession: P49917
Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends.
Other Names:
LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4
Antigen Type: synthetic peptide
Antigen Type: LIG4 {ECO:0000303|PubMed:16357942, ECO:0000312|HGNC:HGNC:6601}
Gene ID: 3981
Primary Accession: P49917
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