Presenilin 2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al.(1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments(endoplasmic reticulum and Golgi complex). Li et al.(1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Description:
Rabbit IgG polyclonal antibody for Presenilin-2 (PSEN2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
AD3L antibody, AD3LP antibody, AD4 antibody, AD5 antibody, Alzheimer disease 4 antibody, CMD1V antibody, E5-1 antibody, OTTHUMP00000035671 antibody, OTTHUMP00000035672 antibody, OTTHUMP00000228286 antibody, OTTHUMP00000228288 antibody, Presenilin 2(Alzheimer disease 4) antibody, Presenilin 2 antibody, Presenilin-2 CTF subunit antibody, PS-2 antibody, PS2 antibody, Psen2 antibody, PSN2_HUMAN antibody, PSNL2 antibody, STM-2 antibody, STM2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2(39-51aa EDGENTAQWRSQE), different from the related mouse and rat sequences by two amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2(39-51aa EDGENTAQWRSQE), different from the related mouse and rat sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.