PRKAR2B Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP14960c
Background:
cAMP is a signaling molecule important for a variety ofcellular functions. cAMP exerts its effects by activating thecAMP-dependent protein kinase, which transduces the signal throughphosphorylation of different target proteins. The inactive kinaseholoenzyme is a tetramer composed of two regulatory and twocatalytic subunits. cAMP causes the dissociation of the inactiveholoenzyme into a dimer of regulatory subunits bound to four cAMPand two free monomeric catalytic subunits. Four differentregulatory subunits and three catalytic subunits have beenidentified in humans. The protein encoded by this gene is one ofthe regulatory subunits. This subunit can be phosphorylated by theactivated catalytic subunit. This subunit has been shown tointeract with and suppress the transcriptional activity of the cAMPresponsive element binding protein 1 (CREB1) in activated T cells.Knockout studies in mice suggest that this subunit may play animportant role in regulating energy balance and adiposity. Thestudies also suggest that this subunit may mediate the geneinduction and cataleptic behavior induced by haloperidol. [providedby RefSeq].
Other Names:
cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B
Gene Name: PRKAR2B
Gene ID: 5577
Primary Accession: P31323
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
cAMP is a signaling molecule important for a variety ofcellular functions. cAMP exerts its effects by activating thecAMP-dependent protein kinase, which transduces the signal throughphosphorylation of different target proteins. The inactive kinaseholoenzyme is a tetramer composed of two regulatory and twocatalytic subunits. cAMP causes the dissociation of the inactiveholoenzyme into a dimer of regulatory subunits bound to four cAMPand two free monomeric catalytic subunits. Four differentregulatory subunits and three catalytic subunits have beenidentified in humans. The protein encoded by this gene is one ofthe regulatory subunits. This subunit can be phosphorylated by theactivated catalytic subunit. This subunit has been shown tointeract with and suppress the transcriptional activity of the cAMPresponsive element binding protein 1 (CREB1) in activated T cells.Knockout studies in mice suggest that this subunit may play animportant role in regulating energy balance and adiposity. Thestudies also suggest that this subunit may mediate the geneinduction and cataleptic behavior induced by haloperidol. [providedby RefSeq].
Other Names:
cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B
Gene Name: PRKAR2B
Gene ID: 5577
Primary Accession: P31323
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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