PRKAR2B polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP14960c
Catalog Number: AC-AP14960c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34541
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34541
Applications: WB
Datasheet
Request Information
Background:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq].
Other Names:
cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B
Target/Specificity:
This PRKAR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-147 amino acids from the Central region of human PRKAR2B.
Antigen Region:
119-147
Antigen Type: Synthetic Peptide
Gene Name: PRKAR2B
Gene ID: 5577
Primary Accession: P31323
NCBI Accession: NP_002727.2
Other Accession: P12369; P31324; P31322; NP_002727.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq].
Other Names:
cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B
Target/Specificity:
This PRKAR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-147 amino acids from the Central region of human PRKAR2B.
Antigen Region:
119-147
Antigen Type: Synthetic Peptide
Gene Name: PRKAR2B
Gene ID: 5577
Primary Accession: P31323
NCBI Accession: NP_002727.2
Other Accession: P12369; P31324; P31322; NP_002727.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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