PRKG1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7386
Background:
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
Alternative Name:
cGK 1, cGK1, cGKI alpha, CGKI, cGKI beta, cGMP-dependent protein kinase 1, cGMP-dependent protein kinase I, DKFZp686K042, FLJ36117, KGP1_HUMAN, KGPB, MGC71944, pkg, PRKG1, PRKG1B, PRKGR1A, PRKGR1B,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: PRKG1 polyclonal antibody detects endogenous levels of PRKG1 protein.
Immunogen:
Recombinant full length Human PRKG1.
MW: ~76 kDa
Swis Prot.: Q13976
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
Alternative Name:
cGK 1, cGK1, cGKI alpha, CGKI, cGKI beta, cGMP-dependent protein kinase 1, cGMP-dependent protein kinase I, DKFZp686K042, FLJ36117, KGP1_HUMAN, KGPB, MGC71944, pkg, PRKG1, PRKG1B, PRKGR1A, PRKGR1B,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: PRKG1 polyclonal antibody detects endogenous levels of PRKG1 protein.
Immunogen:
Recombinant full length Human PRKG1.
MW: ~76 kDa
Swis Prot.: Q13976
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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