PRMT4 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CARM1(coactivator-associated arginine methyltransferase 1), also known as PRMT4, is an enzyme encoded by the CARM1 gene found in human beings, as well as many other mammals. This gene is mapped to 19p13.2. CARM1 is a regulator of cyclin E1 and DHFR mRNA expression. Its main function includes catalyzing the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. CARM1 is a secondary coactivator through its association with p160 family(SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts. This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.

Description:
Rabbit IgG polyclonal antibody for Histone-arginine methyltransferase CARM1 (CARM1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
carm1 antibody, Coactivator associated arginine methyltransferase 1 antibody, Coactivator-associated arginine methyltransferase 1 antibody, Histone arginine methyltransferase CARM 1 antibody, Histone arginine methyltransferase CARM1 antibody, Histone-arginine methyltransferase CARM1 antibody, PRMT 4 antibody, PRMT4 antibody, Protein arginine methyltransferase antibody, Protein arginine N methyltransferase 4 antibody, Protein arginine N-methyltransferase 4 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human PRMT4(267-284aa HLAPFTDEQLYMEQFTKA), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence in the middle region of human PRMT4(267-284aa HLAPFTDEQLYMEQFTKA), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.