PRNP polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
PRNP (prion protein), also known as CD230 or PRP, is a protein that in humans is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al. (1991) identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. PRNP is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid sequences.

Description:
Rabbit IgG polyclonal antibody for Major prion protein (PRNP) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Alternative prion protein; major prion protein antibody, AltPrP antibody, ASCR antibody, atal familial insomnia antibody, CD230 antibody, CD230 antigen antibody, CJD antibody, Creutzfeld Jakob disease antibody, Creutzfeld Jakob Disease Gerstmann Strausler Scheinker Syndrome Fatal Familial Insomnia antibody, Gerstmann-Strausler-Scheinker syndrome antibody, GSS antibody, KURU antibody, Major prion protein antibody, MGC26679 antibody, p27 30 antibody, PRIO_HUMAN antibody, Prion protein antibody, Prion related protein antibody, PRIP antibody, Prni antibody, Prnp antibody, PrP 27-30 antibody, PrP antibody, PrP27 30 antibody, PrP27-30 antibody, PrP33 35C antibody, PrP33-35C antibody, PrPC antibody, PrPSc antibody, Sinc antibody.

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human PRNP recombinant protein (Position: S143-S230).E.coli-derived human PRNP recombinant protein (Position: S143-S230).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat.
Predicted to work with: human.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.