PROC polyclonal, anti-human, mouse, rat

Background:
Protein C is a vitamin K-dependent plasma protein that is produced in the liver and made up of two polypeptide chains. It is an important anti-coagulant activated by Thrombin bound to an endothelial surface receptor and it enzymatically cleaves activated forms of Factors V and VIII, thus inhibiting blood coagulation. Protein C is similar to the prothrombin group of blood coagulation factors in its primary structure. Normal protein C concentration in human plasma is approximately 1-3 ng/ml and the proenzyme concentration is approximately 3 µg/ml. Protein C deficiency is associated with inherited thrombophilia, a rare genetic disorder that predisposes affected individuals to venous thrombosis and habitual abortion.

Alternative Name:
Vitamin K-dependent protein C (EC:3.4.21.69), Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide, PROC

Application Dilution: WB: 1:500~1:1000

Specificity: PROC polyclonal antibody detects endogenous levels of PROC protein.

Immunogen:
A synthetic peptide corresponding to residues in Human PROC.

MW: ~ 52 kDa

Swis Prot.: P04070

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.