Profilin 2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Profilin-2, also called PFN2, is a protein that in humans is encoded by the PFN2 gene. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. This gene is mapped to 3q25.1. It is though to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. It binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Description:
Rabbit IgG polyclonal antibody for Profilin-2 (PFN2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
D3S1319E antibody, PFL antibody, PFN 2 antibody, PFN2 antibody, PROF2_HUMAN antibody, Profilin II antibody, Profilin-2 antibody, Profilin2 antibody, ProfilinII antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Profilin 2(125-140aa NKKAYSMAKYLRDSGF), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human Profilin 2(125-140aa NKKAYSMAKYLRDSGF), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.