Progesterone Receptor (Ser) (clone 608), anti-human, mouse, rat, monkey
€536.00
In stock
SKU
252576
Catalog Nr.: 252576
Size: 0.1 ml
Isotype: Mouse IgG
Applications: E, WB, IHC
Datasheet
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Size: 0.1 ml
Isotype: Mouse IgG
Applications: E, WB, IHC
Datasheet
Request Information
Protein Family: Transcription Factors, Receptors and Channels
Pathway and Disease: Cell Growth and Death, Endocrine System
Description:
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.
Alternate Names: Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C4
Application Notes: E: 1:1,000; IHC: 1:1,000; WB: 1:1,000
Accession No.: P06401
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser294 of human progesterone receptor.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cell Growth and Death, Endocrine System
Description:
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.
Alternate Names: Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C4
Application Notes: E: 1:1,000; IHC: 1:1,000; WB: 1:1,000
Accession No.: P06401
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser294 of human progesterone receptor.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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