Progranulin polyclonal, anti-human

Quantity: 100 µl

Description:
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Synonyms:
Proepithelin, PEPI, PC Cell-derived Growth Factor

Isotype: Guinea pig Polyclonal

Immunogen:
Recombinant human progranulin.

Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

Specificity:
Recognizes human progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.

Reactivity: human

Applications: ELISA, Western Blot

Working DIlution: Optimal conditions must be determined individually for each application.

Storage: 2-8C immediate use, or -20C (aliquoted)