Proinsulin (clone 1C6D6), anti-human antibody
€295.00
In stock
SKU
AC-ABV12094-500
Catalog Number: AC-ABV12094-500
Size: 500 µg
Host: Mouse IgG
Applications: E
Datasheet
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Size: 500 µg
Host: Mouse IgG
Applications: E
Datasheet
Request Information
Background:
Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. It is synthesized in the endoplasmic reticulum, where it is folded and its disulfide bonds are oxidized. It is then transported to the Golgi apparatus where it is packaged into secretory vesicles, and where it is processed by a series of proteases to form mature insulin. Mature insulin has 35 fewer amino acids, 4 are removed altogether, and the remaining 31 forms C‐peptide. The C‐peptide is abstracted from the center of the proinsulin sequence, the two other ends (the B chain and A chain) remain connected by disulfide bonds. Proinsulin Antibody is produced from the hybridoma resulting from fusion of SP2/‐Ag14 myeloma and B‐lymphocytes obtained from mouse immunized with human recombinant proinsulin.
Other Names:
Primary Accession: P01308
Gene Name: INS
Gene ID: 3630
Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. It is synthesized in the endoplasmic reticulum, where it is folded and its disulfide bonds are oxidized. It is then transported to the Golgi apparatus where it is packaged into secretory vesicles, and where it is processed by a series of proteases to form mature insulin. Mature insulin has 35 fewer amino acids, 4 are removed altogether, and the remaining 31 forms C‐peptide. The C‐peptide is abstracted from the center of the proinsulin sequence, the two other ends (the B chain and A chain) remain connected by disulfide bonds. Proinsulin Antibody is produced from the hybridoma resulting from fusion of SP2/‐Ag14 myeloma and B‐lymphocytes obtained from mouse immunized with human recombinant proinsulin.
Other Names:
Primary Accession: P01308
Gene Name: INS
Gene ID: 3630
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