Protein Kinase C [19-35] Peptide 

Protein Family: Protein Kinases, Enzymes

Pathway and Disease: Signal Transduction, Cell Communication, Endocrine System, Immune System, Nervous and Sensory Systems, Cancers, Infectious Diseases

Alternate Names: Protein kinase C alpha type; PKC-alpha; PKC-A; PRKCA; PKCA; PRKACA; Protein kinase C beta type; PKC-beta; PKC-B; PRKCB1; PKCB; PRKCB

Accession No.: P17252, P05771

Description:
This peptide corresponds to the residues 19-35 of the pseudosubstrate domain of protein kinase C isoforms alpha and beta. The peptide is a potent inhibitor of both the phosphorylation of protein kinase C substrates (Ki = 147 nM) and the autophosphorylation of protein kinase C whereas it has a low inhibitory activity on protein kinase A (IC50 = 423 mM).

Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

MW: 2037.4 g/mol

Sequence:
Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-His-Glu-Val-Lys or RFARKGALRQKNVHEVK

Composition:
C89H153N33O22

Purity:
> 95% by HPLC

Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.