Protocadherin-11 rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 7 cadherin domains.,subunit:Interacts with CTNNB1.,tissue specificity:Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.,

Synonyms: PCDH11Y, PCDH11, PCDH22, PCDHY, Protocadherin-11 Y-linked, Protocadherin-11, Protocadherin on the Y chromosome, PCDH-Y, Protocadherin prostate cancer, Protocadherin-PC, Protocadherin-22, PCDH11X, KIAA1326, PCDH11, PCDHX, Protocadherin-11 X-

Gene Name: PCDH11X/PCDH11Y

Gene ID: 83259/27328

SwissProt ID: Q9BZA8/Q9BZA7

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.