PROX1 Blocking Peptide (Center)

Background:
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Other Names:
Prospero homeobox protein 1, Homeobox prospero-like protein PROX1, PROX-1, PROX1

Target/Specificity:
The synthetic peptide sequence is selected from aa 444-458 of HUMAN PROX1

Gene Name: PROX1

Gene ID: 5629
Primary Accession: Q92786
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.