PRPF18 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5866
Background:
PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. A member of the PRP18 family, PRPF18 contains seven WD repeats and exists as two alternatively spliced isoforms which are encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.
Alternative Name:
Pre-mRNA-splicing factor 18, PRP18 homolog, hPRP18, PRP18, HPRP18
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: PRPF18 polyclonal antibody detects endogenous levels of PRPF18 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 223-268 of Human PRPF18.
MW: ~ 40 kDa
Swis Prot.: Q99633
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. A member of the PRP18 family, PRPF18 contains seven WD repeats and exists as two alternatively spliced isoforms which are encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.
Alternative Name:
Pre-mRNA-splicing factor 18, PRP18 homolog, hPRP18, PRP18, HPRP18
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: PRPF18 polyclonal antibody detects endogenous levels of PRPF18 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 223-268 of Human PRPF18.
MW: ~ 40 kDa
Swis Prot.: Q99633
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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