PRPF19 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61565
Background:
The spliceosome, the gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and 5 RNA molecules (U1, U2, U4, U5 and U6). Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19-associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19-associated complex include remodeling of the U6/5' splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.
Alternative Name:
Pre-mRNA-processing factor 19, Nuclear matrix protein 200, PRP19/PSO4 homolog, hPso4, Senescence evasion factor
Application Dilution: WB: 1:500~1:1000
Specificity: PRPF19 polyclonal antibody detects endogenous levels of PRPF19 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 165-209 of Human PRPF19
MW: ~ 55 kDa
Swis Prot.: Q9UMS4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The spliceosome, the gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and 5 RNA molecules (U1, U2, U4, U5 and U6). Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19-associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19-associated complex include remodeling of the U6/5' splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.
Alternative Name:
Pre-mRNA-processing factor 19, Nuclear matrix protein 200, PRP19/PSO4 homolog, hPso4, Senescence evasion factor
Application Dilution: WB: 1:500~1:1000
Specificity: PRPF19 polyclonal antibody detects endogenous levels of PRPF19 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 165-209 of Human PRPF19
MW: ~ 55 kDa
Swis Prot.: Q9UMS4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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