PRPF8 Polyclonal Antibody

Background:
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
220 kDa U5 snRNP specific protein, 220 kDa U5 snRNP-specific protein, Apoptosis regulated protein 1, Apoptosis regulated protein 2, HPRP8, p220, Pre mRNA processing factor 8, Pre mRNA-processing factor 8, S. cerevisiae, homolog of, Pre-mRNA-processing-splicing factor 8, Precursor mRNA processing protein , PRP8, PRP8 homolog, PRP8 pre mRNA processing factor 8 homolog , PRP8, PRPC8, Prpf8, Retinitis pigmentosa 13 (autosomal dominant), RP13, SNRNP220, Splicing factor Prp8, U5 snRNP specific protein , U5 snRNP specific protein (220 kD), ortholog of S. cerevisiae Prp8p

Immunogen: Synthetic peptide of human PRPF8

Swissprot: Q6P2Q9
Gene Accession: NP006436

Calculated MW: 274 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.