PRPH polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71995
Background:
Peripherin is a type III intermediate filament protein that is expressed in peripheral and some central nervous system (CNS) neurons. Peripherin activation is known to be induced by leukemia inhibitory factor (LIF). LIF activates Peripherin by inducing members of STAT transcription factor family to bind to a specific promoter element in the Peripherin gene. IL-6 is also known to induce Peripherin expression. Although it is not essential for neurite formation, peripherin is necessary for cellular intermediate filament network formation. Peripherin, unlike most intermediate filament proteins, has been reported to be modified by tyrosine phosphorylation
Alternative Name:
Peripherin, Neurofilament 4, PRPH, NEF4, PRPH1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:20 - 1:200
Specificity: PRPH polyclonal antibody detects endogenous levels of PRPH protein.
Immunogen:
Recombinant protein of human PRPH
MW: 62kDa
Swis Prot.: P41219
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Peripherin is a type III intermediate filament protein that is expressed in peripheral and some central nervous system (CNS) neurons. Peripherin activation is known to be induced by leukemia inhibitory factor (LIF). LIF activates Peripherin by inducing members of STAT transcription factor family to bind to a specific promoter element in the Peripherin gene. IL-6 is also known to induce Peripherin expression. Although it is not essential for neurite formation, peripherin is necessary for cellular intermediate filament network formation. Peripherin, unlike most intermediate filament proteins, has been reported to be modified by tyrosine phosphorylation
Alternative Name:
Peripherin, Neurofilament 4, PRPH, NEF4, PRPH1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:20 - 1:200
Specificity: PRPH polyclonal antibody detects endogenous levels of PRPH protein.
Immunogen:
Recombinant protein of human PRPH
MW: 62kDa
Swis Prot.: P41219
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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