PRSS8 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60585
Background:
Prostasin, a serine protease first identified in prostate tissue, activates epithelial sodium channels in a variety of tissues. Though typically a membrane-anchored protein, free prostasin is also found in physiologic fluids and tissue culture media, indicating a mechanism for secretion from the cells as well. Aprotinin and other protease inhibitors suppress the channel-activating capacity of prostasin, while aldosterone increases prostasin expression and stimulates sodium uptake. In addition, DNA methylation negatively correlates with prostasin expression in cancer cells, while enforced reexpression decreases invasiveness as well as metastatic potential, implying that prostasin activity reflects epithelial cell physiology.
Alternative Name:
Prostasin, Channel-activating protease 1, CAP1, Serine protease 8, PRSS8
Application Dilution: WB: 1:500~1:1000
Specificity: PRSS8 polyclonal antibody detects endogenous levels of PRSS8 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PRSS8
MW: ~ 36 kDa
Swis Prot.: Q16651
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Prostasin, a serine protease first identified in prostate tissue, activates epithelial sodium channels in a variety of tissues. Though typically a membrane-anchored protein, free prostasin is also found in physiologic fluids and tissue culture media, indicating a mechanism for secretion from the cells as well. Aprotinin and other protease inhibitors suppress the channel-activating capacity of prostasin, while aldosterone increases prostasin expression and stimulates sodium uptake. In addition, DNA methylation negatively correlates with prostasin expression in cancer cells, while enforced reexpression decreases invasiveness as well as metastatic potential, implying that prostasin activity reflects epithelial cell physiology.
Alternative Name:
Prostasin, Channel-activating protease 1, CAP1, Serine protease 8, PRSS8
Application Dilution: WB: 1:500~1:1000
Specificity: PRSS8 polyclonal antibody detects endogenous levels of PRSS8 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PRSS8
MW: ~ 36 kDa
Swis Prot.: Q16651
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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