PSAP antibody (clone 1D1-C12), anti-human
€435.00
In stock
SKU
AC-AT3448a
Catalog Number: AC-AT3448a
Size: 100 µg
Isotype: mouse IgG2a kappa
Applications: WB, IHC, IP
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Size: 100 µg
Isotype: mouse IgG2a kappa
Applications: WB, IHC, IP
Request Information AC-AT3448a">Request Information
Background:
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Other Names:
Prosaposin, Proactivator polypeptide, Saposin-A, Protein A, Saposin-B-Val, Saposin-B, Cerebroside sulfate activator, CSAct, Dispersin, Sphingolipid activator protein 1, SAP-1, Sulfatide/GM1 activator, Saposin-C, A1 activator, Co-beta-glucosidase, Glucosylceramidase activator, Sphingolipid activator protein 2, SAP-2, Saposin-D, Component C, Protein C, PSAP, GLBA, SAP1
Antigen Type:
Recombinant Protein
Gene Name: PSAP
Gene ID: 5660
NCBI Accession: NP_001035930.1;NP_001035931.1;NP_002769.1
Primary Accession: P07602
Other Accession: BC001503
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Other Names:
Prosaposin, Proactivator polypeptide, Saposin-A, Protein A, Saposin-B-Val, Saposin-B, Cerebroside sulfate activator, CSAct, Dispersin, Sphingolipid activator protein 1, SAP-1, Sulfatide/GM1 activator, Saposin-C, A1 activator, Co-beta-glucosidase, Glucosylceramidase activator, Sphingolipid activator protein 2, SAP-2, Saposin-D, Component C, Protein C, PSAP, GLBA, SAP1
Antigen Type:
Recombinant Protein
Gene Name: PSAP
Gene ID: 5660
NCBI Accession: NP_001035930.1;NP_001035931.1;NP_002769.1
Primary Accession: P07602
Other Accession: BC001503
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
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