PSD-95 polyclonal, anti-human, mouse, rat

Protein Family: GTP-binding protein, Protein Kinases, Receptors and Channels, Enzymes

Pathway and Disease: Nervous and Sensory Systems, Neurodegerative Disorders, Signaling Molecules and Interaction, Signal Transduction

Description:
PSD-95 is a molecular scaffolding protein that binds and clusters NMDA receptors at neuronal synapses. PSD-95 is involved in the guanine nucleotide-mediated signal transduction pathway. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. PSD-95 heteromultimerizes with DLG2 and together they are recruited into the same NMDA receptor and potassium channel clusters. They may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.

Alternate Names: PSD-95, Disks large homolog 4, Postsynaptic density protein 95, Synapse-associated protein 90, SAP90, DLG4, PSD95

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P78352

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PSD-95.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Wessel L et al. 2013. Cell Mol Life Sci. doi: 10.1007/s00018-013-1448-4. PMID# 23982753.
[2] Cheng CF et al. 2015. Pain. 156(11): 2295-309. PMID# 26121254.