PSD95 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
DLG4 discs large homolog 4, also known as PSD95 or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase(MAGUK) family. This gene is mapped to 17p13.1. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.

Description:
Rabbit IgG polyclonal antibody for Disks large homolog 4 (DLG4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Discs large homolog 4 antibody, Disks large homolog 4 antibody, DLG 4 antibody, DLG4 antibody, DLG4_HUMAN antibody, FLJ97752 antibody, FLJ98574 antibody, Human post synaptic density protein 95 antibody, Human post-synaptic density protein 95 antibody, Post synaptic density protein 95 antibody, Postsynaptic density protein 95 antibody, PSD 95 antibody, PSD-95 antibody, PSD95 antibody, SAP 90 antibody, SAP-90 antibody, SAP90 antibody, Synapse associated protein 90 antibody, Synapse-associated protein 90 antibody, Tax interaction protein 15 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human PSD95(492-507aa RRVERREWSRLKAKDW), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human PSD95(492-507aa RRVERREWSRLKAKDW), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.