PSEN1 Polyclonal Antibody

Background:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Research Area: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms:
AD3, FAD, PS-1, PS1, S182, Presenilin 1, PSEN1

Immunogen: Recombinant fusion protein of human PSEN1 (NP_015557.2).

Swissprot: P49768
Gene ID: 5663

Calculated MW: 21 kDa/42 kDa/46 kDa/48 kDa/52 kDa
Observed MW: 52 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.