PSEN2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70874
Background:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Alternative Name:
AD4, PS2, AD3L, STM2, CMD1V, Presenilin-2, Presenilin2, Presenilin 2,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: PSEN2 polyclonal antibody detects endogenous levels of PSEN2 protein.
Immunogen:
A synthetic peptide of human PSEN2.
MW: ~ 50 kDa
Swis Prot.: P49810
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Alternative Name:
AD4, PS2, AD3L, STM2, CMD1V, Presenilin-2, Presenilin2, Presenilin 2,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: PSEN2 polyclonal antibody detects endogenous levels of PSEN2 protein.
Immunogen:
A synthetic peptide of human PSEN2.
MW: ~ 50 kDa
Swis Prot.: P49810
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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