PSEN2(Presenilin-2 CTF subunit) Blocking Peptide (C-term)

Background:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Other Names:
Presenilin-2, PS-2, 3423-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2

Target/Specificity:
The synthetic peptide sequence is selected from aa 431-445 of HUMAN PSEN2

Gene Name: PSEN2

Gene ID: 5664
Primary Accession: P49810
Other Accession: O88777; Q0MS45; Q61144; Q9XT96
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.