PSIP1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71250
Background:
The lens epithelium-derived growth factor (LEDGF), also designated p75p52, is a transcriptional coactivator that complexes with the human immunodeficiency virus type 1 (HIV-1) integrase. LEDGF/p75p52 is essential for the nuclear localization and chromosomal association of viral proteins. As the primary integrase-to-chromatin tethering factor for HIV-1, LEDGF/p75p52 is responsible for the cellular trafficking of lentiviral integrases. During apoptosis, LEDGF/p75p52 is cleaved at three sites by caspase-3 and caspase-7, contributing to the pathogenesis of atopic disorders.
Alternative Name:
p52, p75, PAIP, DFS70, LEDGF, PSIP2,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: PSIP1 polyclonal antibody detects endogenous levels of PSIP1 protein.
Immunogen:
Recombinant protein of human PSIP1.
MW: ~ 60 kDa
Swis Prot.: O75475
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The lens epithelium-derived growth factor (LEDGF), also designated p75p52, is a transcriptional coactivator that complexes with the human immunodeficiency virus type 1 (HIV-1) integrase. LEDGF/p75p52 is essential for the nuclear localization and chromosomal association of viral proteins. As the primary integrase-to-chromatin tethering factor for HIV-1, LEDGF/p75p52 is responsible for the cellular trafficking of lentiviral integrases. During apoptosis, LEDGF/p75p52 is cleaved at three sites by caspase-3 and caspase-7, contributing to the pathogenesis of atopic disorders.
Alternative Name:
p52, p75, PAIP, DFS70, LEDGF, PSIP2,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: PSIP1 polyclonal antibody detects endogenous levels of PSIP1 protein.
Immunogen:
Recombinant protein of human PSIP1.
MW: ~ 60 kDa
Swis Prot.: O75475
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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