PSMA3 Polyclonal Antibody

Background:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.

Research Area: Cancer, Cell Biology

Synonyms:
HC8, Macropain subunit C8, MGC12306, MGC32631, Multicatalytic endopeptidase complex subunit C8, Proteasome (prosome macropain) subunit alpha type 3, Proteasome alpha 3 subunit, Proteasome component C8, Proteasome subunit alpha type 3, Proteasome subunit alpha type-3, Proteasome subunit C8, PSA3, PSC8, psmA3

Immunogen: Fusion protein of human PSMA3

Swissprot: P25788
Gene Accession: BC005265

Calculated MW: 28 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.