PSMA6 Polyclonal Antibody

Background:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome.

Research Area: Cancer, Cell Biology

Synonyms:
27 kDa prosomal protein, IOTA, Macropain iota chain, Macropain subunit iota, MGC22756, MGC2333, MGC23846, Multicatalytic endopeptidase complex iota chain, p27K, PROS 27, PROS-27, PROS27, Prosomal P27K protein, Proteasome (prosome macropain) subunit alpha type 6, Proteasome iota chain, Proteasome subunit alpha type 6, Proteasome subunit alpha type-6, Proteasome subunit iota, PSA6, PSMA 6, PSMA6

Immunogen: Fusion protein of human PSMA6

Swissprot: P60900
Gene Accession: BC002979

Calculated MW: 27 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.14 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:50-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.