PSMA7 polyclonal (Center), anti-human, mouse
€0.00
In stock
SKU
AC-AP8659C
Catalog Number: AC-AP8659C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB21043
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB21043
Applications: IHC-P, WB
Datasheet
Request Information
Background:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA7 is a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension.
Other Names:
Proteasome subunit alpha type-7, Proteasome subunit RC6-1, Proteasome subunit XAPC7, PSMA7, HSPC
Target/Specificity:
This PSMA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-126 amino acids from the Central region of human PSMA7.
Antigen Region:
100-126
Antigen Type: Synthetic Peptide
Gene Name: PSMA7
Gene ID: 5688
Primary Accession: O14818
NCBI Accession: NP_002783.1
Other Accession: P48004; Q9Z2U0; Q3ZBG0; Q9PVQ1; Q9PVY6
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA7 is a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension.
Other Names:
Proteasome subunit alpha type-7, Proteasome subunit RC6-1, Proteasome subunit XAPC7, PSMA7, HSPC
Target/Specificity:
This PSMA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-126 amino acids from the Central region of human PSMA7.
Antigen Region:
100-126
Antigen Type: Synthetic Peptide
Gene Name: PSMA7
Gene ID: 5688
Primary Accession: O14818
NCBI Accession: NP_002783.1
Other Accession: P48004; Q9Z2U0; Q3ZBG0; Q9PVQ1; Q9PVY6
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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