PSMB10 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7781
Background:
The 20S proteasome is a protease complex that is responsible for cytosolic protein degradation and generation of peptide ligands for major histocompatabilty complex (MHC) class I molecules, either in their final form or in the form of amino-terminally extended precursors. Upon IFN-gamma stimulation of cells, three constitutively expressed subunits of the 20S proteasome are replaced by inducible subunits LMP2 (low-molecular mass polypeptide 2), LMP7, and MECL-1 (multicatalytic endopeptidase complex-like-1, LMP10). LMP2, LMP7, and MECL-1 subunits form immunoproteasomes, which are associated with more efficient class I antigen processing and presentation. Independent assortment of LMP-2, LMP-7, and MECL-1 into different proteasome complexes can lead to 36 unique proteasome subsets, which may mediate differences in the cleavage specificities/cleavage motifs of proteins subject to constitutive- and immuno-proteasomes.
Alternative Name:
LMP10, Low molecular mass protein 10, Macropain subunit MECl 1, Macropain subunit MECl-1, MECL1, MGC1665, Multicatalytic endopeptidase complex subunit MECl 1, Multicatalytic endopeptidase complex subunit MECl-1, OTTHUMP00000174858, Proteasome (prosome macropain) subunit beta type 10, Proteasome beta 10 subunit, Proteasome catalytic subunit 2i, Proteasome MECl 1, Proteasome MECl-1, Proteasome subunit beta 2i, Proteasome subunit beta 7i, Proteasome subunit beta type 10, Proteasome subunit beta type-10, Proteasome subunit beta-2i, Proteasome subunit MECL1, PSB10_HUMAN, PSMB 10, Psmb10,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: PSMB10 polyclonal antibody detects endogenous levels of PSMB10 protein.
Immunogen:
Recombinant full length Human PSMB10.
MW: ~ 29 kDa
Swis Prot.: P40306
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The 20S proteasome is a protease complex that is responsible for cytosolic protein degradation and generation of peptide ligands for major histocompatabilty complex (MHC) class I molecules, either in their final form or in the form of amino-terminally extended precursors. Upon IFN-gamma stimulation of cells, three constitutively expressed subunits of the 20S proteasome are replaced by inducible subunits LMP2 (low-molecular mass polypeptide 2), LMP7, and MECL-1 (multicatalytic endopeptidase complex-like-1, LMP10). LMP2, LMP7, and MECL-1 subunits form immunoproteasomes, which are associated with more efficient class I antigen processing and presentation. Independent assortment of LMP-2, LMP-7, and MECL-1 into different proteasome complexes can lead to 36 unique proteasome subsets, which may mediate differences in the cleavage specificities/cleavage motifs of proteins subject to constitutive- and immuno-proteasomes.
Alternative Name:
LMP10, Low molecular mass protein 10, Macropain subunit MECl 1, Macropain subunit MECl-1, MECL1, MGC1665, Multicatalytic endopeptidase complex subunit MECl 1, Multicatalytic endopeptidase complex subunit MECl-1, OTTHUMP00000174858, Proteasome (prosome macropain) subunit beta type 10, Proteasome beta 10 subunit, Proteasome catalytic subunit 2i, Proteasome MECl 1, Proteasome MECl-1, Proteasome subunit beta 2i, Proteasome subunit beta 7i, Proteasome subunit beta type 10, Proteasome subunit beta type-10, Proteasome subunit beta-2i, Proteasome subunit MECL1, PSB10_HUMAN, PSMB 10, Psmb10,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: PSMB10 polyclonal antibody detects endogenous levels of PSMB10 protein.
Immunogen:
Recombinant full length Human PSMB10.
MW: ~ 29 kDa
Swis Prot.: P40306
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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