PSMC2 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14584a
Background:
The 26S proteasome is a multicatalytic proteinase complexwith a highly ordered structure composed of 2 complexes, a 20S coreand a 19S regulator. The 20S core is composed of 4 rings of 28non-identical subunits; 2 rings are composed of 7 alpha subunitsand 2 rings are composed of 7 beta subunits. The 19S regulator iscomposed of a base, which contains 6 ATPase subunits and 2non-ATPase subunits, and a lid, which contains up to 10 non-ATPasesubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes one ofthe ATPase subunits, a member of the triple-A family of ATPaseswhich have a chaperone-like activity. This subunit has been shownto interact with several of the basal transcription factors so, inaddition to participation in proteasome functions, this subunit mayparticipate in the regulation of transcription. This subunit mayalso compete with PSMC3 for binding to the HIV tat protein toregulate the interaction between the viral protein and thetranscription complex.
Other Names:
26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, PSMC2, MSS1
Gene Name: PSMC2
Gene ID: 5701
Primary Accession: P35998
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The 26S proteasome is a multicatalytic proteinase complexwith a highly ordered structure composed of 2 complexes, a 20S coreand a 19S regulator. The 20S core is composed of 4 rings of 28non-identical subunits; 2 rings are composed of 7 alpha subunitsand 2 rings are composed of 7 beta subunits. The 19S regulator iscomposed of a base, which contains 6 ATPase subunits and 2non-ATPase subunits, and a lid, which contains up to 10 non-ATPasesubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes one ofthe ATPase subunits, a member of the triple-A family of ATPaseswhich have a chaperone-like activity. This subunit has been shownto interact with several of the basal transcription factors so, inaddition to participation in proteasome functions, this subunit mayparticipate in the regulation of transcription. This subunit mayalso compete with PSMC3 for binding to the HIV tat protein toregulate the interaction between the viral protein and thetranscription complex.
Other Names:
26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, PSMC2, MSS1
Gene Name: PSMC2
Gene ID: 5701
Primary Accession: P35998
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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