PSMC3 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7204
Background:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
Alternative Name:
26S protease regulatory subunit 6A, 26S proteasome AAA-ATPase subunit RPT5, Human immunodeficiency virus tat transactivator binding protein 1, MGC8487, Proteasome (prosome macropain) 26S subunit ATPase 3, Proteasome 26S ATPase subunit 3, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, PRS6A_HUMAN, PSMC 3, PSMC3, Tat binding protein 1, TAT-binding protein 1, TBP-1, TBP1,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: PSMC3 polyclonal antibody detects endogenous levels of PSMC3 protein.
Immunogen:
Recombinant full length Human PSMC3 .
MW: ~ 49 kDa
Swis Prot.: P17980
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
Alternative Name:
26S protease regulatory subunit 6A, 26S proteasome AAA-ATPase subunit RPT5, Human immunodeficiency virus tat transactivator binding protein 1, MGC8487, Proteasome (prosome macropain) 26S subunit ATPase 3, Proteasome 26S ATPase subunit 3, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, PRS6A_HUMAN, PSMC 3, PSMC3, Tat binding protein 1, TAT-binding protein 1, TBP-1, TBP1,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: PSMC3 polyclonal antibody detects endogenous levels of PSMC3 protein.
Immunogen:
Recombinant full length Human PSMC3 .
MW: ~ 49 kDa
Swis Prot.: P17980
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review