PSMD11 Polyclonal Antibody

Background:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene.

Research Area: Cancer, Cell Biology

Synonyms:
26S proteasome non-ATPase regulatory subunit 11, 26S proteasome regulatory subunit 9, 26S proteasome regulatory subunit p44.5, 26S proteasome regulatory subunit RPN6, 26S proteasome regulatory subunit S9, MGC3844, p44.5, protease 26S, subunit, 9, proteasome (prosome, macropain) 26S subunit, non-ATPase, 11, proteasome 26S subunit, non-ATPase, 11, PSD11, PSMD 11, PSMD11, Rpn6, S9

Immunogen: Synthetic peptide of human PSMD11

Swissprot: O00231
Gene Accession: NP_002806

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.8 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-79275/sc-133933