PSME4 Blocking Peptide (N-Term)
€363.00
In stock
SKU
AC-BP21982a
Background:
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Other Names:
Proteasome activator complex subunit 4, Proteasome activator PA200, PSME4, KIAA0077
Target/Specificity:
The synthetic peptide sequence is selected from aa 523-535 of HUMAN PSME4
Gene Name: PSME4
Gene ID: 23198
Primary Accession: Q14997
Other Accession: F1MKX4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Other Names:
Proteasome activator complex subunit 4, Proteasome activator PA200, PSME4, KIAA0077
Target/Specificity:
The synthetic peptide sequence is selected from aa 523-535 of HUMAN PSME4
Gene Name: PSME4
Gene ID: 23198
Primary Accession: Q14997
Other Accession: F1MKX4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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