PSTAIR (clone IL-16), anti-human, mouse, rat, zebrafish, xenopus, hamster, chicken
€445.00
In stock
SKU
251794
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death, Signal Transduction, Cancers
Description:
The cell cycle is controlled in part by cyclin dependent kinases (CDKs) which are themselves controlled by modifications such as phosphorylation of CDKs and formation of complex(es) with other proteins, including the cyclins. CDKs are key regulators of cell cycle progression. CDKs are closely related in size (35-40 kD) and sequence (>40% identity) and associate with and are activated by a cyclin which acts as a regulatory subunit. In every eukaryote examined, CDKs contain an evolutionary conserved 16 amino acid sequence called PSTAIR (EGVPSTAIREISLLKE) which distinguishes them from other protein kinases. The PSTAIR motif is involved in the complex formation with cyclins. The availability of antibodies reacting specifically with the PSTAIR sequence enables the subcellular detection and localization of the various CDKs and examination of substrate interactions, in a variety of organisms.
Alternate Names: PSTAIR, CDK, CDC, Cyclin-dependent kinase, Cell division protein kinase, Cell division control protein
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: Q3U6X7
Antigen: BSA-conjugated synthetic peptide containing the evolutionarily conserved PSTAIR sequence.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death, Signal Transduction, Cancers
Description:
The cell cycle is controlled in part by cyclin dependent kinases (CDKs) which are themselves controlled by modifications such as phosphorylation of CDKs and formation of complex(es) with other proteins, including the cyclins. CDKs are key regulators of cell cycle progression. CDKs are closely related in size (35-40 kD) and sequence (>40% identity) and associate with and are activated by a cyclin which acts as a regulatory subunit. In every eukaryote examined, CDKs contain an evolutionary conserved 16 amino acid sequence called PSTAIR (EGVPSTAIREISLLKE) which distinguishes them from other protein kinases. The PSTAIR motif is involved in the complex formation with cyclins. The availability of antibodies reacting specifically with the PSTAIR sequence enables the subcellular detection and localization of the various CDKs and examination of substrate interactions, in a variety of organisms.
Alternate Names: PSTAIR, CDK, CDC, Cyclin-dependent kinase, Cell division protein kinase, Cell division control protein
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: Q3U6X7
Antigen: BSA-conjugated synthetic peptide containing the evolutionarily conserved PSTAIR sequence.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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