PSTPIP1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.

Synonyms: CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP

Cellular Location: Cell projection Cleavage furrow Cytoplasm cytoskeleton lamellipodium perinuclear region uropodium

Immunogen:
Recombinant protein of human PSTPIP1

Gene Symbol: PSTPIP1

Gene ID: 9051

Swiss prot: O43586

Calculated MW: 48kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.