PTAFR Polyclonal Antibody

Background:
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cardiovascular, Immunology, Signal Transduction

Synonyms:
OTTHUMP00000004041, OTTMUSP00000010350, PAF R, PAF receptor, PAF-R, PAFr, Platelet activating factor receptor, Platelet-activating factor receptor, PTAFR, PTAFR, RP23-470B20.1

Immunogen: Synthetic peptide of human PTAFR

Swissprot: P25105
Gene Accession: NP_000943

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-8741/sc-8742/sc-20732