PTBP1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7296
Background:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
Alternative Name:
57 kDa RNA binding protein PPTB 1, 57 kDa RNA binding protein PPTB1, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, Heterogeneous Nuclear Ribonucleoprotein Polypeptide I, hnRNP I, HNRNP-I, HNRNPI, HNRPI, MGC10830, MGC8461, Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I), Polypyrimidine Tract Binding Protein 1, Polypyrimidine tract binding protein, Polypyrimidine tract-binding protein 1, pPTB, PTB 1, PTB 2, PTB 3, PTB 4, PTB, PTBT, PTB1, PTB2, PTB3, PTB4, PTBP 1, PTBP1, PTBP1_HUMAN, PTBT, RNA Binding Protein,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: PTBP1 polyclonal antibody detects endogenous levels of PTBP1 protein.
Immunogen:
Recombinant full length Human PTBP1.
MW: ~57 kDa
Swis Prot.: P26599
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
Alternative Name:
57 kDa RNA binding protein PPTB 1, 57 kDa RNA binding protein PPTB1, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, Heterogeneous Nuclear Ribonucleoprotein Polypeptide I, hnRNP I, HNRNP-I, HNRNPI, HNRPI, MGC10830, MGC8461, Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I), Polypyrimidine Tract Binding Protein 1, Polypyrimidine tract binding protein, Polypyrimidine tract-binding protein 1, pPTB, PTB 1, PTB 2, PTB 3, PTB 4, PTB, PTBT, PTB1, PTB2, PTB3, PTB4, PTBP 1, PTBP1, PTBP1_HUMAN, PTBT, RNA Binding Protein,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: PTBP1 polyclonal antibody detects endogenous levels of PTBP1 protein.
Immunogen:
Recombinant full length Human PTBP1.
MW: ~57 kDa
Swis Prot.: P26599
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review