PTCH1 polyclonal, anti-human, mouse, rat, xenopus

Protein Family: Receptors and Channels

Pathway and Disease: Cancers, Development and Behavior, Signal Transduction

Description:
PTCH1 is a receptor for sonic hedgehog, indian hedgehog and desert hedgehog that associates with the smoothened protein to transduce the hedgehog's protein signal. Defects in PTCH1 are the cause of several structural anomalies of the brain such as the basal cell nevus syndrome and holoprosencephaly type 7.

Alternate Names: Protein patched homolog 1, PTC, PTC1, PTCH1, PTCH

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IF:1:100-1:500

Accession No.: Q13635, NP_000255

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PTCH1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 15% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
Gordon L. et al. 2010. Developmental Dynamics. 239(11): 2921-2932. PMID# 20931659.